HonorHealth has become the first healthcare provider in Arizona and the Southwest to offer a new leadless cardiac resynchronization therapy (CRT) for patients with advanced heart failure. The system, known as the WiSE System, received approval from the U.S. Food and Drug Administration in April 2025.
The WiSE System is designed to deliver pacing therapy directly from inside the heart’s left ventricle without using external leads. Traditional CRT uses wires, or leads, that can be limited by patient anatomy and carry certain risks. By eliminating these leads, the new technology offers a treatment option for patients who could not receive or did not respond to standard CRT.
“This represents a major leap forward in pacing technology,” said Rahul Doshi, M.D., network electrophysiology director at HonorHealth Heart Care. “By delivering pacing therapy from within the heart, we can provide a more natural activation pattern. This gives patients who previously had no options a chance at improved heart function, better quality of life – and more time with their loved ones.”
The procedure involves placing a small electrode inside the left ventricle of the heart. The electrode is powered wirelessly through an ultrasound transmitter placed under the skin. This approach is intended to mimic natural electrical activity in the heart.
“This is truly transformative,” said Zain Khalpey, M.D., cardiothoracic surgeon at HonorHealth Heart Care and surgical director of the HonorHealth Artificial Heart Program. “For patients who once had no options, this therapy provides a lifeline. By uniting surgical innovation with electrophysiology expertise, we’re not only advancing care but also reaffirming HonorHealth’s leadership in treating advanced heart failure — here in Arizona and across the Southwest.”
Heart failure affects over six million adults in the United States and often causes fatigue, swelling, and decreased quality of life. While it cannot be cured completely, treatments such as CRT can help improve how efficiently the heart works and may improve survival rates for some patients.
The first procedure using this new system was performed by Dr. Doshi in August 2025 at HonorHealth Scottsdale Shea Medical Center.
HonorHealth serves more than five million people throughout greater Phoenix with nine acute-care hospitals and an extensive medical group network.
More information about this therapy is available at HonorHealth.com/heartcare.